Finished Products
비미짐 주
VIMIZIM® Inj.
Classification
Metabolic Agents

Indication/Usage

 

VIMIZIM is indicated for patients with Mucopolysaccharidosis IV type A (MPS IVA, Morquio A syndrome). 

 

 

Dosage/Administration

 

This drug is intended for intravenous administration.
This drug treatment should be supervised by a doctor experienced in the management of patients with Mucopolysaccharidosis IV type A or other inherited metabolic diseases. Administration of this drug should be carried out by an appropriately trained doctor or nurse with the ability to manage medical emergencies. 
The recommended dosage is 2 mg/kg of body weight of this drug administered once a week. The total volume of the infusion should be delivered over approximately 4 hours. As there is a possibility of hypersensitivity reaction, preadministration with antihistamines with or without antipyretics is recommended 30 to 60 minutes prior to the start of the administration.
This drug must be diluted with 0.9% sodium chloride for injection to a total volume of 100 mL or 250 mL based on the patient’s weight, prior to administration. Preparation of this drug for patient’s weighing less than 25 kg, total administration volume should be 100 mL. If the patient weight is 25 kg or more, total administration volume should be 250 mL.
When diluted in 100 mL of 0.9% sodium chloride for injection, the initial administration rate should be 3 mL per hour. The administration rate may be increased as tolerated, every 15 minutes as follows: first increase the rate to 6 mL per hour, then increase the rate every 15 minutes by 6 mL per hour increments until a maximum rate of 36 mL per hour is reached. 
When diluted in 250 mL of 0.9% sodium chloride for injection, the initial administration rate will be 6 mL per hour. The administration rate may be increased as tolerated, every 15 minutes as follows: first increase the rate to 12 mL per hour, then increase the rate every 15 minutes by 12 mL per hour increments until a maximum rate of 72 mL per hour is reached.

 

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